Aptar pharma logo

Aptar Pharma has been continuously developing preservative-free-systems (PFS). Today, we offer state-of-the art technologies, knowledgeable product support and regulatory services designed support pharmaceutical customers in preparing the dispensing part of their finished product dossier.

Absolute Flexibility and Performance at Your Fingertips

 

Aptar-Pharma-Tip-Seal-Technology-Microbiology-Preservative-Free.jpg Aptar-Pharma-Tip-Seal-Technology-Microbiology-Preservative-Free.jpg Aptar-Pharma-Tip-Seal-Technology-Microbiology-Preservative-Free.jpg Aptar-Pharma-Tip-Seal-Technology-Microbiology-Preservative-Free.jpg Aptar-Pharma-Tip-Seal-Technology-Microbiology-Preservative-Free.jpg Aptar-Pharma-Tip-Seal-Technology-Microbiology-Preservative-Free.jpg Aptar-Pharma-Tip-Seal-Technology-Microbiology-Preservative-Free.jpg

  • Debatable Aspects of Preservatives

    Historically used preservatives, such as benzalkonium chloride (BAC), are associated with tolerability issues in patients and can cause side effects. These can impair therapies for long-term or chronic use, e.g. glaucoma treatment in eye-care.

  • Interest for Pure Products Defines the Market

    Sea water, eucalyptus or other natural decongestants, natural eye-drops, but also prescription medicines treating serious conditions are expected to be as pure as possible. This demand creates a growing need for preservative-free solutions for multidose products.

  • Sensitivities for Dermal Treatments

    Due to skin inflammation of most chronic dermatologic diseases, additional sources of irritation -like preservatives- should be avoided. Consumers of skin preparations are used to see preservatives being eliminated from their cosmetic products (paraben).

  • Microbiological Integrity is Key

    Authorities all over the world have reacted to the obvious need for preservative-free solutions in health care and created stringent regulations and requirements when it comes to microbiological safety and integrity.

  • Pharma’s Dispensing Technologies designed to support finished product dossiers

    The Advanced-Preservative-Free system for nasal and topical use  (APF and APFPlus)as well as Aptar Pharma’s Ophthalmic Squeeze Dispenser for preservative-free eye drop delivery (OSD), are provided with a set of data and test methods designed to support pharmaceutical customers in preparing the dispensing part of their finished product dossier.

  • Setting the Benchmark in PFS Technology

    Our purely mechanical Tip-Seal technology in combination with the metal-free fluid-path of our PFSs has been developed for use without preservatives and additives such as silver ions or surface coating. As such Aptar Pharma’s preservative-free technology platform provides well-established packaging solutions for sensitive formulations as well as for preservative-free formulations.

  • Tested for Microbiological Integrity

    Along the market requirements and regulations we have developed microbial challenge procedures simulating relevant in-use scenarios. Customer formulations might require additional testing depending on the properties of their respective formulations.

Next

Search Products

Product Filters

Filter Products By

    Market

    Product Solution

    Features & Technologies

    Regions

    We Have a Broad Range of Value Added Services to Accelerate and Derisk Your Drug Product Development.

    Start a Project With Us

    We Thrive on Transforming Ideas into Opportunities – Let Yours be Next.

    © 2025 Aptar.com. All rights reserved.

    Company

    Legal