Kolibri – The Digital Mesh Nebulizer System for Inhaled Drug Delivery

Kolibri Inhalation Performance

Aptar Pharma’s Non-Propellant Liquid Inhaler (NPLI) platform provides targeted drug delivery to specific areas of the lungs. The breath triggered inhalation control technology ensures doses are administered with ease and only when the user is inhaling. The aerosol generator system can be tailored for optimized performance when delivering specific drug molecules. The sleek, cylindrical design with an integrated mouthpiece, houses specialized digital technology that automatically uploads device data to the cloud for review and analysis.

Kolibri also provides both haptic and digital inhalation feedback, that helps to eliminate user error. All of these innovative features combine to produce a simple, reliable and portable nebulizer system that can deliver a variety of liquid drug formulations to targeted regions of the patient’s lungs.

Kolibri Nebulizer Connect App

The Kolibri Connect App can be loaded onto most smartphones and provide users with a single interface for digital nebulizer data. From therapy reminders to dosing planning, the Connect App helps HCPs and patients stay on the prescribed treatment regimen. The app also provides the user with a personal therapy diary with access to the entire therapy plan history.

In addition to maintaining use data, the Kolibri Connect App also conveniently shares inhalation technique feedback with the user in real-time for optimal drug deposition. The connectivity features of Kolibri also allow centralized therapy control and the integration of additional medications and compatible digital devices into one system.

Intelligent Administration System (iNAS)

Our Intelligent Administration System (iNAS) delivers optimized drug deposition inspiratory flow control. The fully automated system releases the aerosol in the most therapeutically useful phase of inspiration. The integrated feedback loop, available through the Kolibri Connect app, provides the user with direct feedback regarding their specific inhalation technique, and inhaled volume of drug mist. This is form of real-time training for users on achieving optimal inhalation, while avoiding techniques that can compromise drug delivery.

The electronic data sharing features also provide physicians and clinical study centers with additional insight into the compliance with the therapy program. They can use the data to modify the course of ongoing treatment and can more easily interpret complex study results as they happen.

Clinical Applications

Aptar Pharma’s Kolibri vibrating mesh nebulizer systems include the CONNECT-WEB-INTERFACE features that can be used to support clinical study design. It provides a digital centralized interface that can be used to keep up with adherence monitoring from virtually anywhere with an internet connection. In addition, the Kolibri’s digital technology provides individual user inhalation quality data as well as lung performance trend information including:

• Peak expiratory flow (PEF)
• Forced expiratory volume (FEV1)
• Forced vital capacity (FVC)

This data can help the clinical study professionals to evaluate the patient’s lung function, particularly those suffering from respiratory conditions like Asthma or Chronic Obstructive Pulmonary Disease (COPD). Kolibri’s advanced connect-web-interface helps clinical researchers with patient management responsibilities and minimizes the impact of variables on the clinical study results. By automatically selecting relevant parameters, such as flow rate of inhalation, or patient inspiration times, scientists can quickly evaluate each individual study participants data. In the end, analysis of this data can help determine if the patient’s inhalation technique was the cause of unfavorable study results or not. The digital features of Kolibri provide unique opportunities to integrate some third-party devices onto a single data platform.