Pre-filled Syringe Component Platform

Vial Containment Solutions & Syringe Components
Pharmaceutical, Injectables

Enabling your Pre-filled Syringe (PFS) drug development is our top priority. At Aptar Pharma, we have built a comprehensive platform of PFS closure components for your biotech drugs, vaccines and small molecules. As the world leading supplier of Rigid Needle Shields (RNS) we accommodate your injection needs with the widest range of RNS, syringe plunger stoppers and services to support your drug development, auto-injector application.

At Aptar Pharma, we are shaping the future of injectables, together with our Pharma partners.

Aptar Pharma’s platform of PFS solution: Rigid needle shields, plunger & elastomeric closure for pre-filled syringes
Aptar Pharma’s platform of PFS solution: Rigid needle shields, plunger & elastomeric closure for pre-filled syringes

World-Leading Platform of Pre-filled Syringe Components

 

Patient receiving an injection with a pre-filled syringe

How can the support of an expert accelerate your PFS development?

Aptar Pharma is a leading provider of syringe components and pre-filled syringe solutions with more than 50 years of experience in pharma rubber formulation and manufacturing. We serve your pre-filled syringe closure needs with world leading rigid needle shields, plunger stoppers, tip caps and cartridge plungers.

Manufacturing of rubber plunger for pre-filled syringe

Our PFS solutions meet your strictest operational and quality requirements

Our pre-filled syringe solutions are designed to guarantee your dose stability and container closure integrity for your patient safety. Our range of pre-filled syringe plunger stoppers includes PremiumCoat® ETFE film-coated solution to protect the most sensitive drugs, as well as the PremiumFill® quality assurance for increasing your operational efficiency and patient safety.

All our syringe plungers are Ready-to-Sterilize (RTS) and Ready-to-Use (RTU) gamma sterilized with a guarantee of sterility to optimize operational efficiency. We also provide a variety of rapid transfer port bags and standard bags for packaging.

Operation of a Rigid Needle Shield fully automated assembly machine in an ISO classified cleanroom to ensure reproducibility and cleanliness

Our capacity expansion program secures your supply and quality

We are increasing our production capacity in both France and the United States to support growing Pharmaceutical needs for injectable drugs and to ensure our customers’ supply is secure. We have introduced robotic automation and digitalization in our production units for increased efficiency, accuracy, and scalability.

At Aptar Pharma, we are transforming expectations of what an injectables partner can be.

  • Rigid Needle Shields

  • PremiumCoat® Plunger Stoppers

  • Syringe Plungers

  • Cartridge Plungers

  • Tip Caps

  • Aptar Pharma’s Rigid Needle Shield fully-automated, robotized assembly

    World leading formulation and design for your patient safety

    Our world leading rigid needle shields benefit from Aptar Pharma’s recognized formulation and designs to meet the most stringent market requirement.

    Our poly-isoprene formulation is the worldwide best-seller. The styrene butadiene rubber offers ideal chemical performance for most sensitive drugs. Our thermoplastic elastomer rigid needle shields is the only alternative to the market standard for biotech.

  • PremiumCoat® ETFE film-coated syringe plungers for sensitive drug applications

    Protection for your most sensitive drugs

    Pure Bromobutyl formulation combined with a market proven ETFE film-coating and a state-of-the-art process guarantees our lowest level of extractables & leachables. The design of our PremiumCoat® plunger stoppers are demonstrated to be compatible with both vent tube and vacuum stoppering machines, and ensure controlled functional properties for easy injection and auto-injector integration.

  • Manufacturing of rubber plunger for pre-filled syringe

    Guarantee dose safety and closure integrity

    Our range of syringe plungers and stoppers leverage our state-of-the-art Bromobutyl for low extractables and leachables and Chlorobutyl for non-buffered/acidic drugs to ensure compatibility with the drug throughout its life cycle.

    Our plunger stoppers leverage market-proven designs to ensure compatibility and optimal functionality with various pre-filled syringe format.

  • Manufacturing of rubber plunger for pre-filled syringe

    Package your biotech and dental drugs

    Our cartridge plunger designs, and formulations enable easy gliding for accurate dosing with pens. Our market proven Bromobutyl formulation ensures optimal performance in biotech applications. We also have developed a specialized formulation for meeting the requirements of dental anesthetics applications.

  • Mold used for making elastomeric closure components

    Pre-filled closure solution for naked Luer and Luer Lock adapters

    Our unique blended formulation combines high chemical resistance for protecting sensitive drugs and permeability for easy sterilization. Aptar Pharma’s tip caps come in various formats to promote usability, compatibility with Luer Lock adapter or PRTC-like systems to accommodate market specific requirements.

Pre-filled Syringe Components for Biotech Drugs, Vaccines and Delivery of Small Molecules

 

Operator preparing for the robotized molding of injectable closure component, vial stoppers, rigid needle shield or syringe plunger Operator preparing for the robotized molding of injectable closure component, vial stoppers, rigid needle shield or syringe plunger Operator preparing for the robotized molding of injectable closure component, vial stoppers, rigid needle shield or syringe plunger

  • Enable your Biologics and Auto-Injector Drug Delivery

    Our pure Bromobutyl formulation and PremiumCoat® ETFE-film coated plunger stoppers protect sensitive drugs from extractables & leachables. PremiumCoat® plungers are compatible with vent-tube and vacuum filling machines, display exceptional functional performance to promote auto-injectors integration and secure Container Closure Integrity even in cold-storage conditions.

    Our thermoplastic elastomers and styrene butadiene rigid needle shield formulation complement the protection of your most sensitive drugs.

  • Unlock the Potential of your Vaccine Projects

    Our versatile Bromobutyl formulation, a reference on the vaccine market, can be combined to PremiumCoat® ETFE film-coating to protect the most sensitive vaccines and ensure compatibility with high-speed vent tube filling lines.

    The Chlorobutyl formulation, trusted on the market for more than 20 years, limits the generation of particles on high-speed filling lines.

    Our range of rigid needle shields offer ideal machinability and provide protection for healthcare practitioners while our tip caps meet regional preference for luer formats.

  • Meet the Delivery Expectations for your Small Molecules and Generics

    Our versatile Halobutyl syringe plunger can accommodate aggressive solvents, unbuffered solutions or acidic drug formulations.

    Our designs and siliconization strategy enable efficiency on your high-speed filling.

    With a large production capacity, we secure long-term supply to derisk your projects and ensure patients receive their critical dose safely.

Next

Supporting Your Drug Development Needs
with Data, Service Packages and Beyond

 

Aptar Pharma’s expert in rubber formulation and product design holding a pre-filled syringe with a needle shield

At Aptar Pharma, we understand the importance of supporting our Pharma partners as you choose and validate your injectable packaging components. We can support you in many different ways such as providing data packages and/or analytical services, which can help you get to market faster with less risk.

PremiumCoat® Data Packages provide you with all the information, test data and analysis you will need to understand our solution’s performance and help you make a fact-based decision when choosing PremiumCoat®. These data packages include glass container compatibility data (such as Container Closure Integrity Testing, pop-off testing), simulation studies to help anticipate potential issues linked to leachables, and the full extractable file for your regulatory submission.

PremiumCoat® Service Packages leverage the capabilities of our Aptar Pharma Service Companies, providing end-to-end support for your drug development process and validating your choice of primary packaging for your drug.

We also offer a wide range of analytical testing services to  support your specific development needs:

Although our solutions are designed to be versatile, we understand that each project may require a tailor-made approach. That is why we offer customized syringe components and services to meet the unique needs of your project. Our experts are ready to support you in evaluating your requirements and designing the pre-filled syringe plunger stoppers and rigid needle shield and other syringe components, that you need for the success of your drug.

Product Details

 

PremiumCoat® plungers are designed for manual and auto-injector delivery. The 6720GC Bromobutyl formulation, ETFE film available in 1mL & 1-3mL formats are compatible with vent tube & vacuum stoppering machines. Our PremiumCoat® plunger quality ensures the highest levels of dose safety, closure integrity & patient safety. Ready-to-Sterilize & Ready-to-Use, packaged in standard bags or rapid transfer port bags.

We are a leading provider of syringe components and pre-filled syringe solutions with decades of experience in pharmaceutical rubber formulation. Our solutions guarantee dose safety, closure integrity and patient safety. Bromobutyl and Chlorobutyl plungers available Ready-to-Sterilize or Ready-to-Use gamma with PremiumFill® improved specification.

We offer specialized Bromobutyl formulations that ensure optimal container closure integrity and precise dosing for biotech and dental applications.

Our Bromobutyl plungers come with two ribbed designs, allowing for smooth gliding and dependable performance.

We offer a comprehensive range of syringe components and pre-filled syringe solutions, delivering superior dose safety, closure integrity and patient safety. Our proprietary poly-isoprene, styrene butadiene and thermoplastic elastomer (TPE) formulations provide the perfect solution for all pre-filled syringe (PFS) applications. Our specialized design for improved integration in auto-injectors is complemented by our world-leading range of rigid needle shields.

Our syringe components and pre-filled syringe solutions offer optimized chemical and functional properties for closure integrity, dose safety, and patient safety. Our blended formulation provides the ideal compromise between permeability and chemical performance to protect sensitive drugs and enable sterilization. We provide ribbed designs, a Luer Lock adapter, and PRTC-like solutions.

A Complete Platform of Solutions for your Drug Pre-filled Syringe and Auto-Injector Development

We Offer World-Leading Support Services for You at Every Stage of Your Product Development

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