Publications, Pharmaceutical

Acute Migraine Relief: Nose-to-Brain Delivery with Lipid Nanoparticles

Migraine is a widespread and debilitating neurological condition, particularly affecting individuals under the age of 50. Current migraine treatments primarily rely on oral analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) for mild symptoms, while triptans or 5-HT1B/1D receptor agonists are used for moderate to severe cases. However, delivering these medications effectively poses a significant challenge due to the difficulty in crossing the blood-brain barrier, which restricts drug delivery to the brain. This limitation often leads to poor bioavailability and reduced therapeutic efficacy in migraine management.

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Author(s): Joana Torres, University of Porto Renata Silva,University of Porto Gonçalo Farias, Aptar Pharma José Manuel Sousa Lobo, University of Porto Domingos Carvalho Ferreira, University of Porto Ana Catarina Silva, University of Porto
28 Oct 2024

Migraine is a widespread and debilitating neurological condition, particularly affecting individuals under the age of 50. Current migraine treatments primarily rely on oral analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) for mild symptoms, while triptans or 5-HT1B/1D receptor agonists are used for moderate to severe cases. However, delivering these medications effectively poses a significant challenge due to the difficulty in crossing the blood-brain barrier, which restricts drug delivery to the brain. This limitation often leads to poor bioavailability and reduced therapeutic efficacy in migraine management.

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