Publications, Pharmaceutical

Spray Dried Formulations for Nasal Applications – Challenges and Opportunities in Filling and Drug Delivery

Spray dried formulations, which are commonplace for inhaled drug delivery, offer considerable potential for nasal applications. This article describes an experimental study of the behavior of two spray dried formulations for nasal drug delivery, prepared with two different spray dryers under different operating conditions. The resulting formulations were physically characterized and assessed with respect to nasal deposition using a nasal cast (use courtesy of Aptar Pharma/DTF/Univ. of Tours); dose delivery was with an Aptar Pharma Unidose device. The filling performance of the formulations was also assessed. The spray dried formulations performed well in standard filling equipment and high dose deposition was observed in the olfactory region, a primary target for nose to brain drug delivery. Tests suggest minimal penetration to the lungs.

Download Publication
1 Sep 2022

Learn more about Aptar Pharma Expertise
in Nasal Drug Delivery

Find Out More About nasal drug delivery expertise

This Might Also Be of Interest

3 Apr 2024

Delivering Nasally Administered Biologics

Webinars, Pharmaceutical, Innovation & Insights, Device Innovations, Market Insights, Product Solutions

Read More
3 Apr 2024

Nasal Casts, Tools to Enable Nasal Drug Delivery Development

Webinars, Pharmaceutical, Market Insights, Product Solutions, Device Innovations

Read More
26 Mar 2024

Optimizing Preclinical Studies for Intranasal and Pulmonary Programs

Webinars, Pharmaceutical, Innovation & Insights, Device Innovations, Market Insights, Product Solutions

Read More
13 Mar 2024

In Silico Modelling for Orally Inhaled Drug Development (OINDP)

Webinars, Pharmaceutical, Market Insights, Product Solutions, Innovation & Insights

Read More
1 2 3 25
Back To Top