Nasal Drug Development, Trends and Challenges with Nasal Formulations

The confluence of COVID-19, growing recognition of the potential for nose-to-brain drug delivery and the recent success of rapid rescue remedies makes it an exciting time to be working in nasal drug delivery.

This Q&A considers the critical factors that influence nasal drug product development and current trends in formulation practice and science.

The need for a better understanding of precisely where to target nasal drug delivery, and how, is highlighted, along with requirements for better models of mucociliary clearance to tackle the challenge of improving retention. Going forward it is anticipated that nasal drug delivery will be used more, and for a wider range of drugs, notably vaccines and other biologics including mRNA and antibodies.