Pre-filled Syringe Component Platform
Pre-filled Syringe Components
Enabling your Pre-filled Syringe (PFS) drug development is our top priority. At Aptar Pharma, we have built a comprehensive platform of PFS closure components for your biotech drugs, vaccines and small molecules. As the world leading supplier of Rigid Needle Shields (RNS) we accommodate your injection needs with the widest range of RNS, syringe plunger stoppers and services to support your drug development, auto-injector application.
At Aptar Pharma, we are shaping the future of injectables, together with our Pharma partners.Discover our PFS Solutions and Injectables Portfolio
World-Leading Platform of Pre-filled Syringe Components
How can the support of an expert accelerate your PFS development?
Aptar Pharma is a leading provider of syringe components and pre-filled syringe solutions with more than 50 years of experience in pharma rubber formulation and manufacturing. We serve your pre-filled syringe closure needs with world leading rigid needle shields, plunger stoppers, tip caps and cartridge plungers.
Our PFS solutions meet your strictest operational and quality requirements
Our pre-filled syringe solutions are designed to guarantee your dose stability and container closure integrity for your patient safety. Our range of pre-filled syringe plunger stoppers includes PremiumCoat® ETFE film-coated solution to protect the most sensitive drugs, as well as the PremiumFill® quality assurance for increasing your operational efficiency and patient safety.
All our syringe plungers are Ready-to-Sterilize (RTS) and Ready-to-Use (RTU) gamma sterilized with a guarantee of sterility to optimize operational efficiency. We also provide a variety of rapid transfer port bags and standard bags for packaging.
Our capacity expansion program secures your supply and quality
We are increasing our production capacities in both France and the United States to support growing pharmaceutical needs for injectable drugs and to ensure our customers’ supply is secure. We have introduced robotic automation and digitalization in our production units for increased efficiency, accuracy, and scalability.
At Aptar Pharma, we are transforming expectations of what an injectables partner can be.
- Rigid Needle Shields
- PremiumCoat® Plunger Stoppers
- Syringe Plungers
- Cartridge Plungers
- Tip Caps
World leading formulation and design for your patient safety
Our world leading rigid needle shields benefit from Aptar Pharma’s recognized formulation and designs to meet the most stringent market requirement.
Our poly-isoprene formulation is the worldwide best-seller. The styrene butadiene rubber offers ideal chemical performance for most sensitive drugs. Our thermoplastic elastomer rigid needle shields is the only alternative to the market standard for biotech.
Protection for your most sensitive drugs
Pure Bromobutyl formulation combined with a market proven ETFE film-coating and a state-of-the-art process guarantees our lowest level of extractables & leachables. The design of our PremiumCoat® plunger stoppers are demonstrated to be compatible with both vent tube and vacuum stoppering machines, and ensure controlled functional properties for easy injection and auto-injector integration.
Guarantee dose safety and closure integrity
Our range of syringe plungers and stoppers leverage our state-of-the-art Bromobutyl for low extractables and leachables and Chlorobutyl for non-buffered/acidic drugs to ensure compatibility with the drug throughout its life cycle.
Our plunger stoppers leverage market-proven designs to ensure compatibility and optimal functionality with various pre-filled syringe format.
Package your biotech and dental drugs
Our cartridge plunger designs, and formulations enable easy gliding for accurate dosing with pens. Our market proven Bromobutyl formulation ensures optimal performance in biotech applications. We also have developed a specialized formulation for meeting the requirements of dental anesthetics applications.
Pre-filled closure solution for naked Luer and Luer Lock adapters
Our unique blended formulation combines high chemical resistance for protecting sensitive drugs and permeability for easy sterilization. Aptar Pharma’s tip caps come in various formats to promote usability, compatibility with Luer Lock adapter or PRTC-like systems to accommodate market specific requirements.
Pre-filled Syringe Components for Biotech Drugs, Vaccines and Delivery of Small Molecules
Enable your Biologics and Auto-Injector Drug Delivery
Our pure Bromobutyl formulation and PremiumCoat® ETFE-film coated plunger stoppers protect sensitive drugs from extractables & leachables. PremiumCoat® plungers are compatible with vent-tube and vacuum filling machines, display exceptional functional performance to promote auto-injectors integration and secure Container Closure Integrity even in cold-storage conditions.
Our thermoplastic elastomers and styrene butadiene rigid needle shield formulation complement the protection of your most sensitive drugs.
Unlock the Potential of your Vaccine Projects
Our versatile Bromobutyl formulation, a reference on the vaccine market, can be combined to PremiumCoat® ETFE film-coating to protect the most sensitive vaccines and ensure compatibility with high-speed vent tube filling lines.
The Chlorobutyl formulation, trusted on the market for more than 20 years, limits the generation of particles on high-speed filling lines.
Our range of rigid needle shields offer ideal machinability and provide protection for healthcare practitioners while our tip caps meet regional preference for luer formats.
Meet the Delivery Expectations for your Small Molecules and Generics
Our versatile Halobutyl syringe plunger can accommodate aggressive solvents, unbuffered solutions or acidic drug formulations.
Our designs and siliconization strategy enable efficiency on your high-speed filling.
With a large production capacity, we secure long-term supply to derisk your projects and ensure patients receive their critical dose safely.
Supporting Your Drug Development Needs
with Data, Service Packages and Beyond
At Aptar Pharma, we understand the importance of supporting our Pharma partners as you choose and validate your injectable packaging components. We can support you in many different ways such as providing data packages and/or analytical services, which can help you get to market faster with less risk.
PremiumCoat® Data Packages provide you with all the information, test data and analysis you will need to understand our solution’s performance and help you make a fact-based decision when choosing PremiumCoat®. These data packages include glass container compatibility data (such as Container Closure Integrity Testing, pop-off testing), simulation studies to help anticipate potential issues linked to leachables, and the full extractable file for your regulatory submission.
PremiumCoat® Service Packages leverage the capabilities of our Aptar Pharma Service Companies, providing end-to-end support for your drug development process and validating your choice of primary packaging for your drug.
We also offer a wide range of analytical testing services to support your specific development needs:
- Aptar Pharma Services: Device development, project management support and any customizations that you may need
- Gateway Analytical: Analytical services, Extractable and Leachable tests, CCIT testing, particulate detection and more
- Noble: Human factors studies, adherence programs and patient onboarding programs
Although our solutions are designed to be versatile, we understand that each project may require a tailor-made approach. That is why we offer customized syringe components and services to meet the unique needs of your project. Our experts are ready to support you in evaluating your requirements and designing the pre-filled syringe plunger stoppers and rigid needle shield and other syringe components, that you need for the success of your drug.
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