Eliminating the Need for Additives in Multidose Preservative-Free Eye care Formulations

There is a need for cost-effective multidose eye drop delivery systems that allow preservative-free formulations for long-term treatments, such as chronic dry eye and glaucoma. There are a few systems on the market, which claim to work without any preservatives and this article will serve to review the current available systems. One of these is Aptar Pharma’s Ophthalmic Squeeze Dispenser (OSD), a multidose dropper that relies solely on mechanical measures to prevent microbial contamination of the bottle content. It is widely available in Europe and around the world for OTC products, and was recently approved for use with Allergan’s Restasis MultiDose™ eye drops in the US. This system has also been approved by regulatory bodies worldwide for other prescription products, such as for the treatment of increased intraocular pressure.