Publications, Pharmaceutical

Eliminating the Need for Additives in Multidose Preservative-Free Eye care Formulations

There is a need for cost-effective multidose eye drop delivery systems that allow preservative-free formulations for long-term treatments, such as chronic dry eye and glaucoma. There are a few systems on the market, which claim to work without any preservatives and this article will serve to review the current available systems.

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Author(s): Degenhard Marx Matthias Birkhoff
Drug Development & Delivery
1 Oct 2017

One of these is Aptar Pharma’s Ophthalmic Squeeze Dispenser (OSD), a multidose dropper that relies solely on mechanical measures to prevent microbial contamination of the bottle content. It is widely available in Europe and around the world for OTC products, and recently Allergan’s Restasis MultiDose™ eye drops, using Aptar Pharma’s OSD, were approved for the US market. The Ophthalmic Squeeze Dispenser is used with other preservative-free eye care prescription products that have been approved by regulatory bodies worldwide, such as for the treatment of increased intraocular pressure.


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