Publications, Pharmaceutical
Nasal drug delivery has long been used for locally-acting therapeutics for the treatment of, for example, allergic rhinitis. However the accessible, well vascularized nasal cavity also facilitates systemic absorption and is increasingly used for that purpose. This article looks at the history of intranasal drug delivery systems from neti pots and simple droppers through to the sophisticated metered dose nasal sprays in widespread use today. The ongoing evolution to digital devices is highlighted. Easy to use, precise and convenient, modern intranasal drug delivery devices are finding application for delivery of an increasingly broad range of therapeutics, from combination products for topical relief to rescue/emergency medications, vaccines and drugs for the treatments of disorders of the Central Nervous System. The regulatory landscape for nasal drug delivery is discussed.
Nasal drug delivery has been the mainstay for local indications, such as allergic rhinitis, and niche areas, such as pernicious anemia and pain, since the late 1900s. Delivery systems have evolved from less-precise dosing systems to sophisticated device designs able to protect formulations and achieve reliable dosing.
Aptar Pharma is a market leader in nasal spray pumps and we continue to make advances in nasal drug delivery systems, including Digital Healthcare solutions.
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