Unidose (UDS) Liquid Nasal Spray System

Unidose/Bidose Systems


Our Unidose nasal system is a market leader for single-dose nasal spray drug delivery systems. Our Unidose nasal spray systems were specifically designed to deliver a single precise dose in virtually any situation without the need for invasive injections. Aptar Pharma’s Unidose nasal system is so simple to use they can be administered by caregivers, family or even the patient themselves.

The Unidose Liquid Nasal Spray System

Proven technology

As Orally Inhaled and Nasal Drug Product (OINDP) system specialists, Aptar Pharma have supported customers who developed U.S. FDA-approved drug-device combination products commercialized across multiple therapeutic categories and applications including for systemic and local administration.


Accurate and precise single dose delivery

That’s what our Unidose nasal spray system was designed to do. One precise nasal spray dose every time for liquid formulations.


Easy to use and always ready

Ready with no priming or shaking required. Our Unidose nasal spray system is manufactured to offer simplicity of operation. With 360-degree functionality, our system can be administered from nearly any position and no special medical training is required.

Drug reformulation and repositioning

Ideal for repositioning or reformulating existing drugs in a new OINDP delivery format, extending the product’s lifecycle or gaining marketing differentiation.


Emergency use

Our high-quality Unidose delivery system can be integrated into nasal spray delivery devices that do not require any priming or shaking. Compact and convenient to carry, they can help to elevate patient compliance. With its integrated dose indicator, you’ll have confidence in your emergency use device.


Full service-support

Aptar Pharma offers more than just industry-leading single dose nasal spray systems. Our international manufacturing network delivers unrivalled quality and security of supply. We offer fully integrated analytical, development and manufacturing services that can take your idea from formulation to patient.

Commercialized nasal products

Aptar Pharma has been focused on producing leading edge Orally Inhaled and Nasal Drug Product (OINDP) systems for global markets for decades.

Aptar Pharma’s patented Unidose liquid nasal spray system has been successfully approved by the U.S. FDA and European regulatory authorities for a range of molecule types and indications including systemic applications. These approved products are for chronic central nervous system (CNS) conditions such as migraine, epilepsy and pain relief, as well as for emergency lifesaving drugs to treat opioid overdoses or hypoglycemia.

With over 100 million nasal delivery systems sold worldwide, thousands of people use our Unidose nasal spray system every day across a range of treatment scenarios. Combined with our many customer references, Aptar Pharma’s track record of manufacturing quality and compliance for single dose nasal delivery systems is unmatched in the pharmaceutical and biotechnology industries.

Delivers an accurate, single metered dose

Our Unidose nasal spray system was designed to precisely and consistently deliver formulated nasal spray drug products by a single dose.

We designed the nasal spray systems for both intranasal and sublingual therapies, that can meet the needs of application.

Aptar Pharma’s liquid formulation Unidose systems can deliver their full metered dose with reproducible spray performance, even for therapies that require high deposition in nasal or buccal cavity target areas.

Aptar’s Unidose nasal spray systems may be ideal for some drugs that need to quickly enter the central nervous system (CNS). This rapid onset delivery route makes our nasal sprays ideal for emergency use indications.


Aptar Pharma’s Unidose nasal spray system, used in ready-to-use devices, is intuitive and simple for caregivers, family and even patients themselves to use. No priming or shaking required. Just insert in the nostril and depress the actuator to administer the dose. The Unidose nasal spray provides 360° functionality, so the dose can be administered from practically any position. The ease of use makes it ideal for emergency applications when time is of the essence and simplicity of administration can make all the difference.

Drug repositioning opportunities

Aptar Pharma’s Unidose nasal spray system provides a unique opportunity to reposition or repurpose existing drugs from other delivery routes to OINDP devices including nasal sprays. Our expertise and experience in adapting existing drug products to products that use single-dose nasal spray systems has helped numerous partners to extend the lifecycle of their products, respond to unmet patient needs and provide unique brand differentiation.
In general, the nasal drug delivery route can offer the added benefit of fast drug absorption into the bloodstream, producing rapid onset of action. With nasal drug delivery, the drug is delivered directly via the mucosa. The nasal spray delivery route can also provide targeted local or systemic drug delivery and avoids painful needle injections.

Emergency use

Our Unidose nasal spray is used in devices that have a proven track record of being capable of reliably and effectively delivering single doses of drug product in emergency, crisis, rescue or acute use situations. Our single-dose nasal spray system offer biotech and pharmaceutical companies convenient and reliable single-shot intranasal delivery for a variety of medicines including potentially drugs and treatments for severe conditions.

Aptar Pharma has supported customers in the development of new nasal drug formulations for emergency use products to treat everything from life threatening drug overdoses to severe allergic reactions. Many existing treatments for these types of conditions were once limited to injectable needle-based delivery systems.

Aptar Pharma’s Unidose nasal spray system was designed to ensure that critical drug formulations are protected and virtually anyone can administer the drug. And you’ll always know your system is ready to use, with its tamper evident design and integrated dose indicator.

Full service support

Aptar Pharma isn’t just a nasal spray system manufacturer. We can provide full analytical, development and manufacturing services that can take your idea from formulation to patient. We know our OINDP systems used in nasal devices better than anyone and our technical capabilities are comprehensive. Aptar Pharma’s integrated offering means you can accelerate the development and manufacture of your new or existing product by leveraging our decades of experience in creating nasal delivery products.

Our track record means that we can derisk your product throughout the process, from system selection all the way to commercial production. Our step-by-step support includes formulation development, extractables and leachables tests, regulatory guidance and post launch support.

Learn more about Aptar Pharma Services

Unidose (UDS) Liquid Nasal Spray
System Features

  • One-handed Actuation
  • Limits Available Dose
  • Microbiological Integrity
  • Tamper Evident Features
  • Product Differentiation & IP
  • Tamper-Evident Feature
  • Customization & IP
  • Ergonomic Design

Low actuation force allows one-handed administration

The easy-to-use design means that successful administration is possible by non-medical professionals such as parents, caregivers or the patients themselves. This also makes Aptar Pharma’s Unidose nasal spray system attractive for emergency use applications where intuitive and simple administration can make all the difference in saving lives.

Minimize risk of abuse

Aptar Pharma’s Unidose nasal spray system provides only the minimum amount of drug needed in a single convenient dose. This eliminates user access to any excess drug product, particularly in cases where the drug may be addictive or requires a narrow therapeutic index.

Single use system integrity

The microbiological integrity of the nasal spray formulation is always protected within the Unidose system, as the formulation is mixed at the exact moment of use. Aptar Pharma’s Unidose nasal spray systems are single-use, so there is no risk of product contamination from external bacterial.

Know your system is primed and ready

The Unidose system’s design includes clearly visible tamper evident features indicate if the device has already been administered or if it has been tampered with. Patients can confidently know they always have a primed and filled system ready when they need it.

Stand out from the crowd

Aptar Pharma’s Unidose systems offer a variety of customization opportunities that can help to make your product stand out in a crowded marketplace. Product differentiation can help support brand recognition, product differentiation and patient appeal and can even support IP protection for your valuable drug product in certain cases.

Tamper-evident feature protects the drug product

The tamper evident feature indicates if the system has been used before or has been mishandled.

Customization offers IP protection

Customized designs are possible, and we can also offer IP protection for your drug product.

Ergonomic design and style ensures ease of use and accuracy

Patented designs enable steady, one-handed actuation and reliable delivery of a single metered dose.

Product Details

Drug Repositioning & Reformulation Expertise

Aptar Pharma can help bring new life to established drugs through our drug repositioning and lifecycle management services.
Reformulate and differentiate your existing product today.

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