Bidose (BDS) Liquid Nasal Spray System

Accurate and precise Bidose (BDS) nasal delivery

That’s exactly what our two shot nasal spray pump system is designed to do – deliver two precise liquid nasal spray doses from every pre-primed device.

Convenient

Lightweight, compact, leak-resistant, and easy to carry as compared to traditional large and complex autoinjector devices.

Flexible functionality

Ready-to-use with no priming or shaking required. Our Bidose nasal spray device offers 360-degree functionality so the drug product can be administered from virtually any position.

Proven technology

Customers utilizing our Bidose nasal spray device have achieved commercial approval with the U.S. FDA and EMA, with many others in various stages of development.

Delivers two accurate metered nasal spray doses

Our Bidose liquid nasal spray system was designed to precisely and consistently deliver the required amount of drug formulation with each device actuation. We develop some of the most reliable and precise Orally Inhaled and Nasal Drug Product (OINDP) devices, for both intranasal and sublingual therapies, that can meet the needs of virtually any nasal delivery application. Aptar Pharma’s Bidose nasal spray system can reliably deliver fully metered doses with reproducible spray performance even for therapies that require high deposition in nasal or buccal cavity target areas. Aptar Pharma’s Bidose nasal spray pumps are also ideal for many drugs requiring administration via the nose-to-brain pathway, which allows therapeutic compounds to quickly enter the central nervous system (CNS) by targeting the upper part of the nasal cavity, or olfactory region.  In addition, Aptar Pharma’s Bidose nasal spray systems can be used to deliver high dosage products whose formulation can’t be concentrated enough to fit into a single dose nasal spray device. Each dose from our Bidose nasal spray pump device can deliver up to 100 µL per actuation, with a total of 200 µL of nasal spray available from one Bidose nasal spray device.

Flexible 360-degree functionality

Aptar Pharma’s Bidose nasal spray device offers critical 360-degree functionality.  Our Bidose device delivers the precise dose every time from virtually any patient position.  Always pre-primed, there is no need to shake or prepare the device prior to use. This level of functional flexibility demonstrates that Aptar Pharma’s Bidose liquid nasal spray systems are simple to use. They do not require a health care professional (HCP) to administer yet are reliable enough for emergency or acute use applications where fast and simple administration can be the key to saving lives.

Intuitive and easy to use systems

Aptar Pharma’s Bidose nasal spray systems are so simple and easy to use that patients, caregivers and HCPs can use them with ease and confidence. Our Bidose nasal spray systems are so intuitive, they require no special training to operate, so the drug can be administered whenever the patient needs it most. They are always ready-to-use, with no priming or shaking required, even in the most demanding emergency situations.

Drug repositioning opportunities

Aptar Pharma’s Bidose nasal spray device provides a unique opportunity to reposition or repurpose existing drugs from other delivery routes. Whether you call it drug rediscovery, drug reformulation or even lifecycle management, our expertise and experience in adapting existing drug products to the nasal delivery route has helped numerous partners to extend the life of mature products, respond to unmet needs or provide brand differentiation. In some cases, such as with 505(b)2 filings, the drug repositioning process can also benefit from an accelerated regulatory timeline and longer exclusivity. In addition, nasal drug delivery can offer rapid drug absorption into the bloodstream, producing symptom relief sooner. With nasal spray delivery, the drug is delivered via the mucosa, bypassing the need to cross the blood brain barrier (BBB). The nasal delivery route also provides targeted local or systemic drug delivery options which avoid painful needle injections. Our Bidose nasal spray pump can strengthen your lifecycle management and drug reformulation initiatives, helping to bring new life to old drugs.

New world of applications

There is an ever-expanding list of molecule types and indications that are potential applications for Aptar Pharma’s Bidose nasal spray system. Most commonly,  nasal sprays have been used for local treatment of nasal conditions such as allergies and rhinitis.  As the accuracy and reliability of nasal spray devices have improved, the range of possible drug formulations has continued to grow and now includes products for both systemic and Central Nervous System (CNS) applications. Because the nasal mucosa is more vascularized and thinner than the intestinal mucosa, nasal spray drug delivery provides more rapid absorption into the bloodstream than traditional oral dosage forms.  Nasal spray drug delivery also bypasses hepatic and intestinal metabolisms encountered via oral delivery, which slows the absorption process in the gastro-intestinal (GI) system. Nasal delivery provides a fast acting and consistent option for drug delivery.

Emergency / Acute use applications

Because of their portability and reliability, Aptar Pharma’s Bidose nasal spray device has become increasingly attractive for acute or emergency use applications. These can include formulations with rapid onset properties that current oral formulations cannot provide. Parenteral formulations can, in most cases, require administration by a trained Health Care Professional (HCP), making treatment less accessible in emergency situations outside of a medical setting. Complex autoinjector devices may allow individuals to administer emergency treatments quickly but they bring with them the risk of accidental needle sticks or patient hesitancy from fear of needles. Aptar Pharma’s Bidose nasal spray system avoids these challenges with a simple, convenient to carry, robust nasal spray device that consistently delivers precise dosing every time. With 360-degree functionality, Aptar Pharma’s Bidose nasal spray system can be administered from virtually any patient position, and with single hand actuation.  No special medical training is required to administer drug product using our Bidose nasal spray device. Potential emergency use applications that may be suitable for nasal spray delivery include:

• Anxiety disorders
• Anaphylaxis (severe allergy – epinephrine)
• Claustrophobia
• Depression
• Diabetes-related hypoglycemia
• Epileptic seizures
• Heart Arrhythmia (Paroxysmal super-ventricular tachycardia)

Vaccine applications

With the increased importance of vaccines, the market is seeking less invasive and more convenient ways to administer them. Their administration by nasal spray formulations avoids painful and invasive injections, potentially increasing vaccine acceptance by patients of all ages. Aptar Pharma’s Bidose nasal spray system can deliver a dose of vaccine to both nostrils, providing comprehensive coverage of the nasal cavity for optimal vaccine effectiveness.  A range of vaccines could be formulated for a nasal spray device delivery including:

• Covid-19
• Influenza